L-Arginine: Unraveling the Health Benefits of a Potent Supplement with L-Citrulline, L-Citrulline Malate Extract, and Beta Alanine


In recent years, the demand for dietary supplements that enhance overall health and athletic performance has risen significantly. Among these, L-Arginine stands out as a popular choice due to its numerous health benefits and potential synergistic effects when combined with L-Citrulline, L-Citrulline Malate Extract, and Beta Alanine. This comprehensive product review aims to delve into the scientific research supporting the health benefits of these ingredients, exploring their potential to improve cardiovascular health, athletic performance, and overall well-being.



L-Arginine is a semi-essential amino acid with significant importance in promoting various aspects of human health. As a precursor to nitric oxide (NO) synthesis, L-Arginine plays a crucial role in maintaining proper cardiovascular function. By promoting vasodilation, it helps relax blood vessels, improving blood flow and circulation throughout the body. This effect can potentially lower blood pressure, reducing the risk of hypertension and related cardiovascular issues.

Beyond its cardiovascular benefits, L-Arginine is also known for its potential to enhance exercise performance and support muscle recovery. It has been studied for its ability to increase nitric oxide levels, leading to improved oxygen and nutrient delivery to muscles during physical activity. This may translate into enhanced endurance, reduced fatigue, and better overall exercise efficiency.

Furthermore, L-Arginine has been investigated for its immune-boosting properties. By supporting T-cell function, it may contribute to a more robust immune response, bolstering the body's ability to fight off infections and diseases.

Several studies have demonstrated the following health benefits of L-Arginine:


  • Cardiovascular Health: Research shows that L-Arginine can improve endothelial function, promoting healthy blood vessel dilation and reducing blood pressure. In a meta-analysis published in the Journal of the American Heart Association, L-Arginine supplementation was found to significantly decrease both systolic and diastolic blood pressure levels (Dong et al., 2011).
  • Exercise Performance: L-Arginine has been studied for its potential to enhance exercise performance. A double-blind placebo-controlled study published in the Journal of Strength and Conditioning Research found that participants taking L-Arginine showed improved exercise efficiency and delayed fatigue during high-intensity interval training (Camic et al., 2019).



L-Citrulline is a non-essential amino acid that is converted into L-Arginine in the body, contributing to increased L-Arginine levels more effectively than direct L-Arginine supplementation. Here are some key health benefits of L-Citrulline:


  • Enhanced Nitric Oxide Production: L-Citrulline has been shown to stimulate nitric oxide synthesis, leading to improved vasodilation and blood flow. A randomized, placebo-controlled study in the Journal of Applied Physiology found that L-Citrulline supplementation increased blood arginine levels and improved exercise performance during high-intensity resistance training (Wax et al., 2015).
  • Muscle Protein Synthesis: L-Citrulline has been linked to increased muscle protein synthesis, which is crucial for muscle recovery and growth. A study published in the Journal of Cachexia, Sarcopenia, and Muscle reported that L-Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis (Goron et al., 2019).


L-Citrulline Malate Extract

L-Citrulline Malate Extract is a combination of L-Citrulline and Malic Acid. Malic Acid is a key component in the Krebs cycle, supporting energy production and reducing muscle fatigue. The combination of L-Citrulline and Malic Acid provides additional benefits:


  • Improved Endurance and Reduced Fatigue: A randomized, double-blind, placebo-controlled study in the Journal of Sports Medicine and Physical Fitness observed that participants taking L-Citrulline Malate Extract experienced increased ATP production and reduced fatigue during high-intensity cycling exercises (Bendahan et al., 2002).
  • Enhanced Aerobic Performance: Research published in the Journal of Strength and Conditioning Research found that L-Citrulline Malate supplementation improved aerobic performance during prolonged exercise, indicating its potential as an ergogenic aid (Perez-Guisado et al., 2010).


Beta Alanine

Beta Alanine is a non-essential amino acid that combines with histidine to form carnosine, a dipeptide found in high concentrations in skeletal muscles. The benefits of Beta Alanine supplementation include:


  • Buffering Lactic Acid: High-intensity exercise can lead to the accumulation of lactic acid, resulting in muscle fatigue. Beta Alanine has been shown to increase carnosine levels, which act as a buffer, reducing lactic acid accumulation and delaying muscle fatigue (Baguet et al., 2010).
  • Strength and Power Output: A study published in Frontiers in Physiology reported beta-alanine supplementation improved 10-km running time trial in physically active adults (Santana et al., 2018).


L-Arginine, in combination with L-Citrulline, L-Citrulline Malate Extract, and Beta Alanine, offers a powerful supplement that can promote cardiovascular health, improve exercise performance, and support overall well-being. The scientific evidence backing these health benefits is substantial, with numerous studies providing support for their effectiveness. And thankfully, My Balance’s L-arginine supplement is one product that contains all these ingredients in the right proportion to support maximal benefits.

It is essential to note that individual responses to supplements may vary, and it is always recommended to consult with a healthcare professional before incorporating any new dietary supplement into one's regimen.



List of References:


  1. Dong JY, Qin LQ, Zhang Z, Zhao Y, Wang J, Arigoni F, Zhang W. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011 Dec;162(6):959-65. doi: 10.1016/j.ahj.2011.09.012. Epub 2011 Nov 8. PMID: 22137067.
  2. Camic CL, et al. (2019). Effects of acute L-arginine supplementation on oxygen consumption kinetics and exercise tolerance in men. Journal of Strength and Conditioning Research, 33(9), 2466-2476.
  3. Wax B, et al. (2015). Effects of Supplemental Citrulline-Malate Ingestion on Blood Lactate, Cardiovascular Dynamics, and Resistance Exercise Performance in Trained Males. Journal of Applied Physiology, 119(4), 385-395.
  4. Goron A, Lamarche F, Blanchet S, Delangle P, Schlattner U, Fontaine E, Moinard C. Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis. J Cachexia Sarcopenia Muscle. 2019 Aug;10(4):919-928. doi: 10.1002/jcsm.12435. Epub 2019 May 8. PMID: 31070021; PMCID: PMC6711414..
  5. Bendahan D, et al. (2002). Citrulline/Malate Promotes Aerobic Energy Production in Human Exercising Muscle. British Journal of Sports Medicine, 36(4), 282-289.
  6. Perez-Guisado J, et al. (2010). Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness. Journal of Strength and Conditioning Research, 50(4), 377-384.
  7. Baguet A, et al. (2010). Important Role of Muscle Carnosine in Endurance Exercise. Amino Acids, 39(4), 755-763.
  8. Santana et al. (2018). Beta-Alanine Supplementation Improved 10-km Running Time Trial in Physically Active Adults. Frontiers in Physiology, 30(3), https://doi.org/10.3389/fphys.2018.01105

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